Conformational ensemble of native α-synuclein in solution as determined by short-distance crosslinking constraint-guided discrete molecular dynamics simulations

Combining structural proteomics experimental data with computational methods is a powerful tool for protein structure prediction. Here, we apply a recently-developed approach for de novo protein structure determination based on the incorporation of short-distance crosslinking data as constraints in...

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Detalles Bibliográficos
Autores principales: Brodie, Nicholas I., Popov, Konstantin I., Petrotchenko, Evgeniy V., Dokholyan, Nikolay V., Borchers, Christoph H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453469/
https://www.ncbi.nlm.nih.gov/pubmed/30917118
http://dx.doi.org/10.1371/journal.pcbi.1006859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453469/
https://www.ncbi.nlm.nih.gov/pubmed/30917118
http://dx.doi.org/10.1371/journal.pcbi.1006859

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