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mRNA-Based Protein Replacement Therapy for the Heart

Myocardial infarction (MI) and heart failure (HF) are the leading causes of death in the United States and in most other industrialized nations. MI leads to a massive loss of cardiomyocytes (CMs), which are replaced with non-CM cells, leading to scarring and, in most cases, HF. The adult mammalian h...

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Detalles Bibliográficos
Autores principales: Magadum, Ajit, Kaur, Keerat, Zangi, Lior
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453506/
https://www.ncbi.nlm.nih.gov/pubmed/30611663
http://dx.doi.org/10.1016/j.ymthe.2018.11.018