Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness

To achieve maximal growth, cells must manage a massive economy of ribosomal proteins (r-proteins) and RNAs (rRNAs) to produce thousands of ribosomes every minute. Although ribosomes are essential in all cells, natural disruptions to ribosome biogenesis lead to heterogeneous phenotypes. Here, we mode...

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Detalles Bibliográficos
Autores principales: Tye, Blake W, Commins, Nicoletta, Ryazanova, Lillia V, Wühr, Martin, Springer, Michael, Pincus, David, Churchman, L Stirling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453566/
https://www.ncbi.nlm.nih.gov/pubmed/30843788
http://dx.doi.org/10.7554/eLife.43002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453566/
https://www.ncbi.nlm.nih.gov/pubmed/30843788
http://dx.doi.org/10.7554/eLife.43002

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