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Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness

To achieve maximal growth, cells must manage a massive economy of ribosomal proteins (r-proteins) and RNAs (rRNAs) to produce thousands of ribosomes every minute. Although ribosomes are essential in all cells, natural disruptions to ribosome biogenesis lead to heterogeneous phenotypes. Here, we mode...

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Detalles Bibliográficos
Autores principales:	Tye, Blake W, Commins, Nicoletta, Ryazanova, Lillia V, Wühr, Martin, Springer, Michael, Pincus, David, Churchman, L Stirling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453566/ https://www.ncbi.nlm.nih.gov/pubmed/30843788 http://dx.doi.org/10.7554/eLife.43002

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