Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

We find that variation in the dbt-1 gene underlies natural differences in Caenorhabditis elegans responses to the toxin arsenic. This gene encodes the E2 subunit of the branched-chain α-keto acid dehydrogenase (BCKDH) complex, a core component of branched-chain amino acid (BCAA) metabolism. We causa...

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Detalles Bibliográficos
Autores principales: Zdraljevic, Stefan, Fox, Bennett William, Strand, Christine, Panda, Oishika, Tenjo, Francisco J, Brady, Shannon C, Crombie, Tim A, Doench, John G, Schroeder, Frank C, Andersen, Erik C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453569/
https://www.ncbi.nlm.nih.gov/pubmed/30958264
http://dx.doi.org/10.7554/eLife.40260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453569/
https://www.ncbi.nlm.nih.gov/pubmed/30958264
http://dx.doi.org/10.7554/eLife.40260

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