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Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

We find that variation in the dbt-1 gene underlies natural differences in Caenorhabditis elegans responses to the toxin arsenic. This gene encodes the E2 subunit of the branched-chain α-keto acid dehydrogenase (BCKDH) complex, a core component of branched-chain amino acid (BCAA) metabolism. We causa...

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Detalles Bibliográficos
Autores principales:	Zdraljevic, Stefan, Fox, Bennett William, Strand, Christine, Panda, Oishika, Tenjo, Francisco J, Brady, Shannon C, Crombie, Tim A, Doench, John G, Schroeder, Frank C, Andersen, Erik C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Evolutionary Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453569/ https://www.ncbi.nlm.nih.gov/pubmed/30958264 http://dx.doi.org/10.7554/eLife.40260

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