TMCO1-mediated Ca(2+) leak underlies osteoblast functions via CaMKII signaling

Transmembrane and coiled-coil domains 1 (TMCO1) is a recently identified Ca(2+) leak channel in the endoplasmic reticulum. TMCO1 dysfunction in humans is associated with dysmorphism, mental retardation, glaucoma and the occurrence of cancer. Here we show an essential role of TMCO1 in osteogenesis me...

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Detalles Bibliográficos
Autores principales: Li, Jianwei, Liu, Caizhi, Li, Yuheng, Zheng, Qiaoxia, Xu, Youjia, Liu, Beibei, Sun, Weijia, Li, Yuan, Ji, Shuhui, Liu, Mingwei, Zhang, Jing, Zhao, Dingsheng, Du, Ruikai, Liu, Zizhong, Zhong, Guohui, Sun, Cuiwei, Wang, Yanqing, Song, Jinping, Zhang, Shu, Qin, Jun, Ling, Shukuan, Wang, Xianhua, Li, Yingxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453895/
https://www.ncbi.nlm.nih.gov/pubmed/30962442
http://dx.doi.org/10.1038/s41467-019-09653-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453895/
https://www.ncbi.nlm.nih.gov/pubmed/30962442
http://dx.doi.org/10.1038/s41467-019-09653-5

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