Residues 529 to 549 participate in membrane penetration and pore-forming activity of the Bordetella adenylate cyclase toxin

The adenylate cyclase toxin-hemolysin (CyaA, ACT or AC-Hly) of pathogenic Bordetellae delivers its adenylyl cyclase (AC) enzyme domain into the cytosol of host cells and catalyzes uncontrolled conversion of cellular ATP to cAMP. In parallel, the toxin forms small cation-selective pores that permeabi...

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Detalles Bibliográficos
Autores principales: Roderova, Jana, Osickova, Adriana, Sukova, Anna, Mikusova, Gabriela, Fiser, Radovan, Sebo, Peter, Osicka, Radim, Masin, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453906/
https://www.ncbi.nlm.nih.gov/pubmed/30962483
http://dx.doi.org/10.1038/s41598-019-42200-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453906/
https://www.ncbi.nlm.nih.gov/pubmed/30962483
http://dx.doi.org/10.1038/s41598-019-42200-2

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