On resin click-chemistry-mediated synthesis of novel enkephalin analogues with potent anti-nociceptive activity

Here, we report the chemical synthesis of two DPDPE analogues 7a (NOVA1) and 7b (NOVA2). This entailed the solid-phase synthesis of two enkephalin precursor chains followed by a Cu(I)-catalyzed azide-alkyne cycloaddition, with the aim of improving in vivo analgesic efficacy versus DPDPE. NOVA2 showe...

Descripción completa

Detalles Bibliográficos
Autores principales: Stefanucci, Azzurra, Lei, Wei, Pieretti, Stefano, Novellino, Ettore, Dimmito, Marilisa Pia, Marzoli, Francesca, Streicher, John M., Mollica, Adriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453917/
https://www.ncbi.nlm.nih.gov/pubmed/30962495
http://dx.doi.org/10.1038/s41598-019-42289-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453917/
https://www.ncbi.nlm.nih.gov/pubmed/30962495
http://dx.doi.org/10.1038/s41598-019-42289-5

Ejemplares similares