Improving designer glycan production in Escherichia coli through model-guided metabolic engineering

Asparagine-linked (N-linked) glycosylation is the most common protein modification in eukaryotes, affecting over two-thirds of the proteome. Glycosylation is also critical to the pharmacokinetic activity and immunogenicity of many therapeutic proteins currently produced in complex eukaryotic hosts....

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Detalles Bibliográficos
Autores principales: Wayman, Joseph A., Glasscock, Cameron, Mansell, Thomas J., DeLisa, Matthew P., Varner, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454127/
https://www.ncbi.nlm.nih.gov/pubmed/31008057
http://dx.doi.org/10.1016/j.mec.2019.e00088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454127/
https://www.ncbi.nlm.nih.gov/pubmed/31008057
http://dx.doi.org/10.1016/j.mec.2019.e00088

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