A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase

[Image: see text] Biosynthesis of 6-deoxy sugars, including l-fucose, involves a mechanistically complex, enzymatic 4,6-dehydration of hexose nucleotide precursors as the first committed step. Here, we determined pre- and postcatalytic complex structures of the human GDP-mannose 4,6-dehydratase at a...

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Detalles Bibliográficos
Autores principales: Pfeiffer, Martin, Johansson, Catrine, Krojer, Tobias, Kavanagh, Kathryn L, Oppermann, Udo, Nidetzky, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454399/
https://www.ncbi.nlm.nih.gov/pubmed/30984471
http://dx.doi.org/10.1021/acscatal.9b00064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454399/
https://www.ncbi.nlm.nih.gov/pubmed/30984471
http://dx.doi.org/10.1021/acscatal.9b00064

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