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A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase
[Image: see text] Biosynthesis of 6-deoxy sugars, including l-fucose, involves a mechanistically complex, enzymatic 4,6-dehydration of hexose nucleotide precursors as the first committed step. Here, we determined pre- and postcatalytic complex structures of the human GDP-mannose 4,6-dehydratase at a...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454399/ https://www.ncbi.nlm.nih.gov/pubmed/30984471 http://dx.doi.org/10.1021/acscatal.9b00064 |