The pro-apoptotic JNK scaffold POSH/SH3RF1 mediates CHMP2B(Intron5)-associated toxicity in animal models of frontotemporal dementia

Frontotemporal dementia (FTD) is one of the most prevalent forms of early-onset dementia. However, the pathological mechanisms driving neuronal atrophy in FTD remain poorly understood. Here we identify a conserved role for the novel pro-apoptotic protein plenty of SH3s (POSH)/SH3 domain containing r...

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Detalles Bibliográficos
Autores principales: West, Ryan J H, Ugbode, Chris, Gao, Fen-Biao, Sweeney, Sean T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454437/
https://www.ncbi.nlm.nih.gov/pubmed/29432529
http://dx.doi.org/10.1093/hmg/ddy048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454437/
https://www.ncbi.nlm.nih.gov/pubmed/29432529
http://dx.doi.org/10.1093/hmg/ddy048

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