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The pro-apoptotic JNK scaffold POSH/SH3RF1 mediates CHMP2B(Intron5)-associated toxicity in animal models of frontotemporal dementia
Frontotemporal dementia (FTD) is one of the most prevalent forms of early-onset dementia. However, the pathological mechanisms driving neuronal atrophy in FTD remain poorly understood. Here we identify a conserved role for the novel pro-apoptotic protein plenty of SH3s (POSH)/SH3 domain containing r...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454437/ https://www.ncbi.nlm.nih.gov/pubmed/29432529 http://dx.doi.org/10.1093/hmg/ddy048 |