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Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

BACKGROUND: The manipulation of dendritic cells (DCs) for cancer vaccination has not reached its full potential, despite the revolution in cancer immunotherapy. DCs are fundamental for CD8+ T cell activation, which relies on cross-presentation of exogenous antigen on MHC-I and can be fostered by imm...

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Detalles Bibliográficos
Autores principales: Wculek, Stefanie K., Amores-Iniesta, Joaquín, Conde-Garrosa, Ruth, Khouili, Sofía C., Melero, Ignacio, Sancho, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454603/
https://www.ncbi.nlm.nih.gov/pubmed/30961656
http://dx.doi.org/10.1186/s40425-019-0565-5