Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice

Huntington’s disease (HD) is a neurodegenerative disorder caused by a genetic abnormality in the huntingtin gene that leads to a polyglutamine repeat expansion of the huntingtin protein. The cleaved polyglutamine expansion of mutant huntingtin (mHTT) protein can form aggregates strongly correlated w...

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Detalles Bibliográficos
Autores principales: Abd-Elrahman, Khaled S., Ferguson, Stephen S. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454676/
https://www.ncbi.nlm.nih.gov/pubmed/30961637
http://dx.doi.org/10.1186/s13041-019-0456-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454676/
https://www.ncbi.nlm.nih.gov/pubmed/30961637
http://dx.doi.org/10.1186/s13041-019-0456-1

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