Interactions between vitamin D binding protein variants and major dietary patterns on the odds of metabolic syndrome and its components in apparently healthy adults

BACKGROUND: Recent studies have shown that the risks of chronic diseases resulting from high-risk alleles, such as cardiovascular diseases and metabolic syndrome (MetS), can be affected by various dietary patterns. Among the genes affected by environmental factors are those associated with vitamin D...

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Autores principales: Rahimi, Mohammad Hossein, Mollahosseini, Mehdi, Mirzababaei, Atieh, Yekaninejad, Mir Saeed, Maghbooli, Zhila, Mirzaei, Khadijeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454781/
https://www.ncbi.nlm.nih.gov/pubmed/31007727
http://dx.doi.org/10.1186/s13098-019-0422-1
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author Rahimi, Mohammad Hossein
Mollahosseini, Mehdi
Mirzababaei, Atieh
Yekaninejad, Mir Saeed
Maghbooli, Zhila
Mirzaei, Khadijeh
author_facet Rahimi, Mohammad Hossein
Mollahosseini, Mehdi
Mirzababaei, Atieh
Yekaninejad, Mir Saeed
Maghbooli, Zhila
Mirzaei, Khadijeh
author_sort Rahimi, Mohammad Hossein
collection PubMed
description BACKGROUND: Recent studies have shown that the risks of chronic diseases resulting from high-risk alleles, such as cardiovascular diseases and metabolic syndrome (MetS), can be affected by various dietary patterns. Among the genes affected by environmental factors are those associated with vitamin D binding protein (DBP). METHODS: This cross-sectional study was conducted on a random sample of 265 apparently healthy adults aged 18–50. MetS was defined according to the adult treatment panel III criteria. Major dietary patterns were determined using factor analysis on 24 food groups, using a valid and reliable 147-item food frequency questionnaire (FFQ). DBP genotypes were determined by polymerase chain reactions–restriction fragment length polymorphism (PCR–RFLP). RESULTS: After adjustment for confounder factors, results demonstrated strong interactions between, on the one hand, a high intake of healthy pattern and DBP haplotype (rs7041/rs4588 major alleles) and on the other, low MetS odds (OR = 0.64, 95% CI 0.47–0.87, P ≤ 0.001), serum triglyceride levels (OR = 0.72, 95% CI 0.56–0.93, P = 0.01) and fasting blood glucose (OR = 0.36, 95% CI 0.14–0.96, P = 0.04). Also, individuals with a higher adherence to traditional dietary patterns demonstrated reduced odds of high waist circumference among the major allele (low-risk allele) carriers of rs7041/rs4588 (OR = 0.69, 95% CI 0.55–0.88, P = 0. 003). Interactions were also seen between high traditional pattern intake and DBP haplotype elevated blood pressure odds (OR = 1.31, 95% CI 1.02–1.68, P = 0.02). CONCLUSIONS: The present evidence indicates that interactions between healthy dietary patterns with DBP haplotypes (Gc 1F, Gc 1S and Gc 2) and traditional dietary patterns with DBP haplotypes may be effective in reducing the odds of MetS and some of its components through consuming healthy food groups and inherited low risk alleles.
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spelling pubmed-64547812019-04-19 Interactions between vitamin D binding protein variants and major dietary patterns on the odds of metabolic syndrome and its components in apparently healthy adults Rahimi, Mohammad Hossein Mollahosseini, Mehdi Mirzababaei, Atieh Yekaninejad, Mir Saeed Maghbooli, Zhila Mirzaei, Khadijeh Diabetol Metab Syndr Research BACKGROUND: Recent studies have shown that the risks of chronic diseases resulting from high-risk alleles, such as cardiovascular diseases and metabolic syndrome (MetS), can be affected by various dietary patterns. Among the genes affected by environmental factors are those associated with vitamin D binding protein (DBP). METHODS: This cross-sectional study was conducted on a random sample of 265 apparently healthy adults aged 18–50. MetS was defined according to the adult treatment panel III criteria. Major dietary patterns were determined using factor analysis on 24 food groups, using a valid and reliable 147-item food frequency questionnaire (FFQ). DBP genotypes were determined by polymerase chain reactions–restriction fragment length polymorphism (PCR–RFLP). RESULTS: After adjustment for confounder factors, results demonstrated strong interactions between, on the one hand, a high intake of healthy pattern and DBP haplotype (rs7041/rs4588 major alleles) and on the other, low MetS odds (OR = 0.64, 95% CI 0.47–0.87, P ≤ 0.001), serum triglyceride levels (OR = 0.72, 95% CI 0.56–0.93, P = 0.01) and fasting blood glucose (OR = 0.36, 95% CI 0.14–0.96, P = 0.04). Also, individuals with a higher adherence to traditional dietary patterns demonstrated reduced odds of high waist circumference among the major allele (low-risk allele) carriers of rs7041/rs4588 (OR = 0.69, 95% CI 0.55–0.88, P = 0. 003). Interactions were also seen between high traditional pattern intake and DBP haplotype elevated blood pressure odds (OR = 1.31, 95% CI 1.02–1.68, P = 0.02). CONCLUSIONS: The present evidence indicates that interactions between healthy dietary patterns with DBP haplotypes (Gc 1F, Gc 1S and Gc 2) and traditional dietary patterns with DBP haplotypes may be effective in reducing the odds of MetS and some of its components through consuming healthy food groups and inherited low risk alleles. BioMed Central 2019-04-08 /pmc/articles/PMC6454781/ /pubmed/31007727 http://dx.doi.org/10.1186/s13098-019-0422-1 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Rahimi, Mohammad Hossein
Mollahosseini, Mehdi
Mirzababaei, Atieh
Yekaninejad, Mir Saeed
Maghbooli, Zhila
Mirzaei, Khadijeh
Interactions between vitamin D binding protein variants and major dietary patterns on the odds of metabolic syndrome and its components in apparently healthy adults
title Interactions between vitamin D binding protein variants and major dietary patterns on the odds of metabolic syndrome and its components in apparently healthy adults
title_full Interactions between vitamin D binding protein variants and major dietary patterns on the odds of metabolic syndrome and its components in apparently healthy adults
title_fullStr Interactions between vitamin D binding protein variants and major dietary patterns on the odds of metabolic syndrome and its components in apparently healthy adults
title_full_unstemmed Interactions between vitamin D binding protein variants and major dietary patterns on the odds of metabolic syndrome and its components in apparently healthy adults
title_short Interactions between vitamin D binding protein variants and major dietary patterns on the odds of metabolic syndrome and its components in apparently healthy adults
title_sort interactions between vitamin d binding protein variants and major dietary patterns on the odds of metabolic syndrome and its components in apparently healthy adults
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454781/
https://www.ncbi.nlm.nih.gov/pubmed/31007727
http://dx.doi.org/10.1186/s13098-019-0422-1
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