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Vedolizumab for chronic antibiotic-refractory pouchitis

BACKGROUND: Chronic antibiotic-refractory pouchitis (CARP) is a complication of ileal pouch-anal anastomosis (IPAA), which poses a therapeutic challenge. Vedolizumab, a gut-selective monoclonal antibody to the α4β7 of integrin, has been used in such patients, but data on its efficacy are limited. Ou...

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Detalles Bibliográficos
Autores principales: Singh, Amandeep, Khan, Freeha, Lopez, Rocio, Shen, Bo, Philpott, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454848/
https://www.ncbi.nlm.nih.gov/pubmed/30976425
http://dx.doi.org/10.1093/gastro/goz001