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Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing CXorf21

Background: CXorf21 and SLC15a4 both contain risk alleles for systemic lupus erythematosus (SLE) and Sjögren's syndrome (pSS). The former escapes X inactivation. Our group predicts specific endolysosomal-dependent immune responses are driven by the protein products of these genes, which form a...

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Detalles Bibliográficos
Autores principales: Harris, Valerie M., Harley, Isaac T. W., Kurien, Biji T., Koelsch, Kristi A., Scofield, Robert Hal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454867/
https://www.ncbi.nlm.nih.gov/pubmed/31001245
http://dx.doi.org/10.3389/fimmu.2019.00578