Icariin Attenuates M1 Activation of Microglia and Aβ Plaque Accumulation in the Hippocampus and Prefrontal Cortex by Up-Regulating PPARγ in Restraint/Isolation-Stressed APP/PS1 Mice

BACKGROUND: Studies have shown that psychosocial stress is involved in Alzheimer’s disease (AD) pathogenesis; it induces M1 microglia polarization and production of pro-inflammatory cytokines, leading to neurotoxic outcomes and decreased β-amyloid (Aβ) clearance. Icariin has been proven to be an eff...

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Detalles Bibliográficos
Autores principales: Wang, Yihe, Zhu, Tianrui, Wang, Min, Zhang, Feng, Zhang, Guitao, Zhao, Jing, Zhang, Yuanyuan, Wu, Erxi, Li, Xiaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455051/
https://www.ncbi.nlm.nih.gov/pubmed/31001073
http://dx.doi.org/10.3389/fnins.2019.00291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455051/
https://www.ncbi.nlm.nih.gov/pubmed/31001073
http://dx.doi.org/10.3389/fnins.2019.00291

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