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Icariin Attenuates M1 Activation of Microglia and Aβ Plaque Accumulation in the Hippocampus and Prefrontal Cortex by Up-Regulating PPARγ in Restraint/Isolation-Stressed APP/PS1 Mice

BACKGROUND: Studies have shown that psychosocial stress is involved in Alzheimer’s disease (AD) pathogenesis; it induces M1 microglia polarization and production of pro-inflammatory cytokines, leading to neurotoxic outcomes and decreased β-amyloid (Aβ) clearance. Icariin has been proven to be an eff...

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Detalles Bibliográficos
Autores principales:	Wang, Yihe, Zhu, Tianrui, Wang, Min, Zhang, Feng, Zhang, Guitao, Zhao, Jing, Zhang, Yuanyuan, Wu, Erxi, Li, Xiaohong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455051/ https://www.ncbi.nlm.nih.gov/pubmed/31001073 http://dx.doi.org/10.3389/fnins.2019.00291

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