Estimating genome-wide off-target effects for pyrrole-imidazole polyamide binding by a pathway-based expression profiling approach

In the search for new pharmaceutical leads, especially with DNA-binding molecules or genome editing methods, the issue of side and off-target effects have always been thorny in nature. A particular case is the investigation into the off-target effects of N-methylpyrrole-N-methylimidazole polyamides,...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Jason, Krishnamurthy, Sakthisri, Yoda, Hiroyuki, Shinozaki, Yoshinao, Watanabe, Takayoshi, Koshikawa, Nobuko, Takatori, Atsushi, Horton, Paul, Nagase, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456183/
https://www.ncbi.nlm.nih.gov/pubmed/30964912
http://dx.doi.org/10.1371/journal.pone.0215247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456183/
https://www.ncbi.nlm.nih.gov/pubmed/30964912
http://dx.doi.org/10.1371/journal.pone.0215247

Ejemplares similares