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Deletion of Dtnbp1 in mice impairs threat memory consolidation and is associated with enhanced inhibitory drive in the amygdala

Schizophrenia is a severe and highly heritable disorder. Dystrobrevin-binding protein 1 (DTNBP1), also known as dysbindin-1, has been implicated in the pathophysiology of schizophrenia. Specifically, dysbindin-1 mRNA and protein expression are decreased in the brains of subjects with this disorder....

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Detalles Bibliográficos
Autores principales: Huang, Cathy C. Y., Muszynski, Kevin J., Bolshakov, Vadim Y., Balu, Darrick T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456574/
https://www.ncbi.nlm.nih.gov/pubmed/30967545
http://dx.doi.org/10.1038/s41398-019-0465-y