Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses

BACKGROUND: Post-transcriptional gene silencing (PTGS) by short interfering RNA has opened up new directions in the phenotypic mutation of cellular genes. However, its efficacy on non-nuclear genes and its effect on the interferon pathway remain unexplored. Since directed mutation of RNA genomes is...

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Detalles Bibliográficos
Autores principales: Bitko, Vira, Barik, Sailen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64570/
https://www.ncbi.nlm.nih.gov/pubmed/11801185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64570/
https://www.ncbi.nlm.nih.gov/pubmed/11801185

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