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A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation
In humans, β-amyloid and islet amyloid polypeptide (IAPP, also known as amylin) aggregations are linked to Alzheimer's disease and type-2 diabetes, respectively. There is significant interest in better understanding the aggregation process by using chemical tools. Here, we show the ability of a...
Autores principales: | Sahoo, Bikash R., Genjo, Takuya, Nakayama, Takahiro W., Stoddard, Andrea K., Ando, Toshio, Yasuhara, Kazuma, Fierke, Carol A., Ramamoorthy, Ayyalusamy |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457205/ https://www.ncbi.nlm.nih.gov/pubmed/31015938 http://dx.doi.org/10.1039/c8sc05771k |
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