Proline bulky substituents consecutively act as steric hindrances and directing groups in a Michael/Conia-ene cascade reaction under synergistic catalysis

In this study, we report a highly stereoselective and versatile synthesis of spiro pyrazolones, promising motifs that are being employed as pharmacophores. The new synthetic strategy merges organocatalysis and metal catalysis to create a synergistic catalysis using proline derivatives and Pd catalys...

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Detalles Bibliográficos
Autores principales: Putatunda, Salil, Alegre-Requena, Juan V., Meazza, Marta, Franc, Michael, Rohal'ová, Dominika, Vemuri, Pooja, Císařová, Ivana, Herrera, Raquel P., Rios, Ramon, Veselý, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457335/
https://www.ncbi.nlm.nih.gov/pubmed/31015949
http://dx.doi.org/10.1039/c8sc05258a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457335/
https://www.ncbi.nlm.nih.gov/pubmed/31015949
http://dx.doi.org/10.1039/c8sc05258a

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