Accurate design of translational output by a neural network model of ribosome distribution

Synonymous codon choice can have dramatic effects on ribosome speed and protein expression. Ribosome profiling experiments have underscored that ribosomes do not move uniformly along mRNAs. We modeled this variation in translation elongation using a feedforward neural network to predict the ribosome...

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Detalles Bibliográficos
Autores principales: Tunney, Robert, McGlincy, Nicholas J, Graham, Monica E, Naddaf, Nicki, Pachter, Lior, Lareau, Liana F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457438/
https://www.ncbi.nlm.nih.gov/pubmed/29967537
http://dx.doi.org/10.1038/s41594-018-0080-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457438/
https://www.ncbi.nlm.nih.gov/pubmed/29967537
http://dx.doi.org/10.1038/s41594-018-0080-2

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