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Accurate design of translational output by a neural network model of ribosome distribution
Synonymous codon choice can have dramatic effects on ribosome speed and protein expression. Ribosome profiling experiments have underscored that ribosomes do not move uniformly along mRNAs. We modeled this variation in translation elongation using a feedforward neural network to predict the ribosome...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457438/ https://www.ncbi.nlm.nih.gov/pubmed/29967537 http://dx.doi.org/10.1038/s41594-018-0080-2 |