Comparative analysis of homologous aminopeptidase PepN from pathogenic and non-pathogenic mycobacteria reveals divergent traits

Mycobacterium tuberculosis (Mtb) secretes proteases and peptidases to subjugate its host. Out of its sixty plus proteases, atleast three are reported to reach host macrophages. In this study, we show that Mtb also delivers a lysyl alanine aminopeptidase, PepN (Rv2467) into host macrophage cytosol. O...

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Detalles Bibliográficos
Autores principales: Sharma, Nishant, Aggarwal, Suruchi, Kumar, Saravanan, Sharma, Rahul, Choudhury, Konika, Singh, Niti, Jayaswal, Praapti, Goel, Renu, Wajid, Saima, Yadav, Amit Kumar, Atmakuri, Krishnamohan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457555/
https://www.ncbi.nlm.nih.gov/pubmed/30969995
http://dx.doi.org/10.1371/journal.pone.0215123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457555/
https://www.ncbi.nlm.nih.gov/pubmed/30969995
http://dx.doi.org/10.1371/journal.pone.0215123

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