Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures

Organoid cultures derived from colorectal cancer (CRC) samples are increasingly used as preclinical models for studying tumor biology and the effects of targeted therapies under conditions capturing in vitro the genetic make-up of heterogeneous and even individual neoplasms. While 3D cultures are in...

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Detalles Bibliográficos
Autores principales: Schumacher, Dirk, Andrieux, Geoffroy, Boehnke, Karsten, Keil, Marlen, Silvestri, Alessandra, Silvestrov, Maxine, Keilholz, Ulrich, Haybaeck, Johannes, Erdmann, Gerrit, Sachse, Christoph, Templin, Markus, Hoffmann, Jens, Boerries, Melanie, Schäfer, Reinhold, Regenbrecht, Christian R. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457557/
https://www.ncbi.nlm.nih.gov/pubmed/30925167
http://dx.doi.org/10.1371/journal.pgen.1008076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457557/
https://www.ncbi.nlm.nih.gov/pubmed/30925167
http://dx.doi.org/10.1371/journal.pgen.1008076

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