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A Comprehensive Biophysical Analysis of the Effect of DNA Binding Drugs on Protamine-induced DNA Condensation

DNA condensation is a ubiquitous phenomenon in biology, yet the physical basis for it has remained elusive. Here, we have explored the mechanism of DNA condensation through the protamine-DNA interaction, and by examining on it the influence of DNA binding drugs. We observed that the DNA condensation...

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Detalles Bibliográficos
Autores principales: Gupta, Sakshi, Tiwari, Neha, Munde, Manoj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458161/
https://www.ncbi.nlm.nih.gov/pubmed/30971720
http://dx.doi.org/10.1038/s41598-019-41975-8