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Roles of cellular heterogeneity, intrinsic and extrinsic noise in variability of p53 oscillation
The p53 protein is a key mediator of the cellular response to various stress signals. In response to DNA damage, the concentration of p53 can temporally oscillate with fluctuations in both the amplitude and period. The underlying mechanism for p53 variability is not fully understood. Here, we constr...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458166/ https://www.ncbi.nlm.nih.gov/pubmed/30971810 http://dx.doi.org/10.1038/s41598-019-41904-9 |