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Depletion of ATP-Citrate Lyase (ATPCL) Affects Chromosome Integrity Without Altering Histone Acetylation in Drosophila Mitotic Cells

The Citrate Lyase (ACL) is the main cytosolic enzyme that converts the citrate exported from mitochondria by the SLC25A1 carrier in Acetyl Coenzyme A (acetyl-CoA) and oxaloacetate. Acetyl-CoA is a high-energy intermediate common to a large number of metabolic processes including protein acetylation...

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Detalles Bibliográficos
Autores principales: Morciano, Patrizia, Di Giorgio, Maria Laura, Porrazzo, Antonella, Licursi, Valerio, Negri, Rodolfo, Rong, Yikang, Cenci, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458238/
https://www.ncbi.nlm.nih.gov/pubmed/31019471
http://dx.doi.org/10.3389/fphys.2019.00383