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A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury

BACKGROUND: Neuroinflammation is an essential player in many neurological diseases including traumatic brain injury (TBI). Recent studies have identified that inflammasome complexes are responsible for inflammatory responses in many pathological conditions. Inflammasomes are intracellular multiprote...

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Detalles Bibliográficos
Autores principales: Kuwar, Ram, Rolfe, Andrew, Di, Long, Xu, Hongyu, He, Liu, Jiang, Yuqi, Zhang, Shijun, Sun, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458637/
https://www.ncbi.nlm.nih.gov/pubmed/30975164
http://dx.doi.org/10.1186/s12974-019-1471-y