Cargando…

Study protocol: exploring the efficacy of cyclophosphamide added to corticosteroids for treating acute exacerbation of idiopathic pulmonary fibrosis; a randomized double-blind, placebo-controlled, multi-center phase III trial (EXAFIP)

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, with a median survival of 2–3 years and variable natural history, characterized by gradual and progressive deterioration. Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe complication, associated with po...

Descripción completa

Detalles Bibliográficos
Autores principales:	Naccache, Jean-Marc, Montil, Melissa, Cadranel, Jacques, Cachanado, Marine, Cottin, Vincent, Crestani, Bruno, Valeyre, Dominique, Wallaert, Benoit, Simon, Tabassome, Nunes, Hilario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458697/ https://www.ncbi.nlm.nih.gov/pubmed/30971235 http://dx.doi.org/10.1186/s12890-019-0830-x

Ejemplares similares

The MUC5B Variant Is Associated with Idiopathic Pulmonary Fibrosis but Not with Systemic Sclerosis Interstitial Lung Disease in the European Caucasian Population
por: Borie, Raphael, et al.
Publicado: (2013)

Gender Differences in Idiopathic Pulmonary Fibrosis: Are Men and Women Equal?
por: Sesé, Lucile, et al.
Publicado: (2021)

Adherence to guidelines in idiopathic pulmonary fibrosis: a follow-up national survey
por: Cottin, Vincent, et al.
Publicado: (2015)

Early and comprehensive care bundle in the elderly for acute heart failure in the emergency department: study protocol of the ELISABETH stepped-wedge cluster randomized trial
por: Freund, Yonathan, et al.
Publicado: (2019)

Rituximab for auto-immune alveolar proteinosis, a real life cohort study
por: Soyez, Berenice, et al.
Publicado: (2018)

The natural history of adult pulmonary Langerhans cell histiocytosis: a prospective multicentre study
por: Tazi, Abdellatif, et al.
Publicado: (2015)

Familial vs. sporadic sarcoidosis: BTNL2 polymorphisms, clinical presentations, and outcomes in a French cohort
por: Pacheco, Yves, et al.
Publicado: (2016)

Sarcoidosis
por: Nunes, Hilario, et al.
Publicado: (2007)

Effect of intravenous almitrine on intubation or mortality in patients with COVID-19 acute hypoxemic respiratory failure: A multicentre, randomised, double-blind, placebo-controlled trial
por: Kalfon, Pierre, et al.
Publicado: (2022)

MOdified DIagnostic strateGy to safely ruLe-out pulmonary embolism In the emergency depArtment: study protocol for the Non-Inferiority MODIGLIANI cluster cross-over randomized trial
por: Philippon, Anne-Laure, et al.
Publicado: (2020)

Extrathoracic investigation in adult patients with isolated pulmonary langerhans cell histiocytosis
por: Tazi, Abdellatif, et al.
Publicado: (2016)

Diagnosis and management of idiopathic pulmonary fibrosis: French practical guidelines
por: Cottin, Vincent, et al.
Publicado: (2014)

Differential diagnosis of pulmonary sarcoidosis: a review
por: Valeyre, Dominique, et al.
Publicado: (2023)

Two-Year Follow-up Study of Membranous Nephropathy Treated With Tacrolimus and Corticosteroids Versus Cyclical Corticosteroids and Cyclophosphamide
por: Ramachandran, Raja, et al.
Publicado: (2017)

Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study
por: Sokol, Harry, et al.
Publicado: (2020)

Rituximab Therapy for Severe Cutaneous Leukocytoclastic Angiitis Refractory to Corticosteroids, Cellcept and Cyclophosphamide
por: El-Reshaid, Kamel, et al.
Publicado: (2013)

Nebulized corticosteroids in the management of acute exacerbation of COPD
por: Gaude, G. S., et al.
Publicado: (2010)

PReS-FINAL-2172: Efficacy of corticosteroids and intravenous cyclophosphamide for patients with juvenile systemic sclerosis
por: Kikuchi, M, et al.
Publicado: (2013)

Effect of Ultrasonography-Guided Corticosteroid Injection vs Placebo Added to Exercise Therapy for Achilles Tendinopathy: A Randomized Clinical Trial
por: Johannsen, Finn, et al.
Publicado: (2022)

Acute exacerbations of idiopathic pulmonary fibrosis and the role of corticosteroids
por: Brereton, Christopher J., et al.
Publicado: (2020)

Cost-effectiveness of modified diagnostic strategy to safely rule-out pulmonary embolism in the emergency department: a non-inferiority cluster crossover randomized trial (MODIGLIA-NI)
por: Nze Ossima, Arnaud, et al.
Publicado: (2023)

Cyclophosphamide for the treatment of Acute Exacerbation of Interstitial Lung Disease: A Review of the Literature
por: Innabi, Ayoub, et al.
Publicado: (2021)

Biliary reconstruction with or without an intraductal removable stent in liver transplantation: study protocol for a randomized controlled trial
por: Goumard, Claire, et al.
Publicado: (2015)

Successful treatment of HIV-associated tumefactive demyelinating lesions with corticosteroids and cyclophosphamide: a case report
por: Lazzarin, Serena Marita, et al.
Publicado: (2020)

Corticosteroids in the treatment of acute exacerbations of chronic obstructive pulmonary disease
por: Woods, J Andrew, et al.
Publicado: (2014)

Non-adherence to inhaled corticosteroids and the risk of asthma exacerbations in children
por: Vasbinder, Erwin C, et al.
Publicado: (2016)

No evidence for a pathogen associated with pulmonary MALT lymphoma: a metagenomics investigation
por: Borie, Raphaël, et al.
Publicado: (2021)

Initial therapeutic dose of corticosteroid for an acute exacerbation of IPF is associated with subsequent early recurrence of another exacerbation
por: Yamazaki, Ryo, et al.
Publicado: (2021)

Immunogenicity and reactogenicity of heterologous and homologous mRNA-1273 and BNT162b2 vaccination: A multicenter non-inferiority randomized trial
por: Janssen, Cécile, et al.
Publicado: (2022)

Management of sarcoidosis in clinical practice
por: Jeny, Florence, et al.
Publicado: (2016)

Cost-effectiveness of adding rituximab to fludarabine and cyclophosphamide for treatment of chronic lymphocytic leukemia in Ukraine
por: Mandrik, Olena, et al.
Publicado: (2015)

Presumed late recurrence of Acanthamoeba keratitis exacerbated by exposure to topical corticosteroids
por: Patel, Dipika V, et al.
Publicado: (2013)

Blood eosinophils: a biomarker of COPD exacerbation reduction with inhaled corticosteroids
por: Siddiqui, Salman H, et al.
Publicado: (2018)

Blood eosinophilia, use of inhaled corticosteroids, and risk of COPD exacerbations and mortality
por: Oshagbemi, Olorunfemi A., et al.
Publicado: (2018)

Inhaled Corticosteroid use and the Risk of Pneumonia and COPD Exacerbations in the UPLIFT Study
por: Morjaria, Jaymin B., et al.
Publicado: (2017)

Role of Inhaled Corticosteroids for Asthma Exacerbation in Children: An Updated Meta-Analysis
por: Sawanyawisuth, Kanlayanee, et al.
Publicado: (2020)

Genetic Signatures of Acute Asthma Exacerbation Related With Ineffective Response to Corticosteroid
por: Kang, Min-Gyu, et al.
Publicado: (2020)

Relationship Between Blood Eosinophils and Systemic Corticosteroid Therapy in COPD Exacerbation
por: Gong, Yaya, et al.
Publicado: (2022)

Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis
por: Jeny, Florence, et al.
Publicado: (2021)

How to Tackle the Diagnosis and Treatment in the Diverse Scenarios of Extrapulmonary Sarcoidosis
por: Valeyre, Dominique, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_e50jjo4bqiq5gbao392te2oa1k