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Hyperosmotic Stress Initiates AMPK-Independent Autophagy and AMPK- and Autophagy-Independent Depletion of Thioredoxin 1 and Glyoxalase 2 in HT22 Nerve Cells

BACKGROUND: Hyperosmotic stress is an important pathophysiologic condition in diabetes, severe trauma, dehydration, infection, and ischemia. Furthermore, brain neuronal cells face hyperosmotic stress in ageing and Alzheimer's disease. Despite the enormous importance of knowing the homeostatic m...

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Detalles Bibliográficos
Autores principales: Dafre, Alcir Luiz, Schmitz, Ariana Ern, Maher, Pamela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458930/
https://www.ncbi.nlm.nih.gov/pubmed/31049129
http://dx.doi.org/10.1155/2019/2715810