Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response

Precise gene editing in hematopoietic stem and progenitor cells (HSPCs) holds promise for treating genetic diseases. However, responses triggered by programmable nucleases in HSPCs are poorly characterized and may negatively impact HSPC engraftment and long-term repopulation capacity. Here, we induc...

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Detalles Bibliográficos
Autores principales: Schiroli, Giulia, Conti, Anastasia, Ferrari, Samuele, della Volpe, Lucrezia, Jacob, Aurelien, Albano, Luisa, Beretta, Stefano, Calabria, Andrea, Vavassori, Valentina, Gasparini, Patrizia, Salataj, Eralda, Ndiaye-Lobry, Delphine, Brombin, Chiara, Chaumeil, Julie, Montini, Eugenio, Merelli, Ivan, Genovese, Pietro, Naldini, Luigi, Di Micco, Raffaella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458988/
https://www.ncbi.nlm.nih.gov/pubmed/30905619
http://dx.doi.org/10.1016/j.stem.2019.02.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458988/
https://www.ncbi.nlm.nih.gov/pubmed/30905619
http://dx.doi.org/10.1016/j.stem.2019.02.019

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