SMYD2-OE promotes oxaliplatin resistance in colon cancer through MDR1/P-glycoprotein via MEK/ERK/AP1 pathway

BACKGROUND: SET and MYND domain-containing protein 2 (SMYD2-OE) plays an important role in cancer development through methylating histone and non-histone proteins. However, little is known about the relevance of SMYD2-OE in colon cancer. Moreover, oxaliplatin (L-OHP) is applied as first line for col...

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Detalles Bibliográficos
Autores principales: Ren, Hailiang, Wang, Zheng, Chen, Yao, Liu, Yanjun, Zhang, Shu, Zhang, Tongtong, Li, Yuntao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459156/
https://www.ncbi.nlm.nih.gov/pubmed/31040701
http://dx.doi.org/10.2147/OTT.S186806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459156/
https://www.ncbi.nlm.nih.gov/pubmed/31040701
http://dx.doi.org/10.2147/OTT.S186806

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