Cargando…
Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1
SIRT1, a NAD+-dependent deacetylase, protects neurons in a variety of in vitro and in vivo models of neurodegenerative disease. We have previously described a neuroprotective effect by SIRT1 independent of its catalytic activity. To confirm this conclusion we tested a panel of SIRT1 deletion mutant...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459503/ https://www.ncbi.nlm.nih.gov/pubmed/30973934 http://dx.doi.org/10.1371/journal.pone.0215208 |