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Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1

SIRT1, a NAD+-dependent deacetylase, protects neurons in a variety of in vitro and in vivo models of neurodegenerative disease. We have previously described a neuroprotective effect by SIRT1 independent of its catalytic activity. To confirm this conclusion we tested a panel of SIRT1 deletion mutant...

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Detalles Bibliográficos
Autores principales: Pfister, Jason A., Ma, Chi, D’Mello, Santosh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459503/
https://www.ncbi.nlm.nih.gov/pubmed/30973934
http://dx.doi.org/10.1371/journal.pone.0215208

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