Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease

Alzheimer’s disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease. Loss of function of the nuclear receptor REV-ERB is associated with reduced cognitive function in mouse models. The effect of enhance...

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Detalles Bibliográficos
Autores principales: Roby, Deborah A., Ruiz, Fernanda, Kermath, Bailey A., Voorhees, Jaymie R., Niehoff, Michael, Zhang, Jinsong, Morley, John E., Musiek, Erik S., Farr, Susan A., Burris, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459530/
https://www.ncbi.nlm.nih.gov/pubmed/30973894
http://dx.doi.org/10.1371/journal.pone.0215004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459530/
https://www.ncbi.nlm.nih.gov/pubmed/30973894
http://dx.doi.org/10.1371/journal.pone.0215004

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