Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity

Unfolded protein responses (UPRs) safeguard cellular function during proteotoxic stress and aging. In a previous paper (Lehrbach and Ruvkun, 2016) we showed that the ER-associated SKN-1A/Nrf1 transcription factor activates proteasome subunit expression in response to proteasome dysfunction, but it w...

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Detalles Bibliográficos
Autores principales: Lehrbach, Nicolas J, Ruvkun, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459674/
https://www.ncbi.nlm.nih.gov/pubmed/30973820
http://dx.doi.org/10.7554/eLife.44425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459674/
https://www.ncbi.nlm.nih.gov/pubmed/30973820
http://dx.doi.org/10.7554/eLife.44425

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