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Higher levels of B‐cell mutation in the early germinal centres of an inefficient secondary antibody response to a variant influenza haemagglutinin

Designing improved vaccines against mutable viruses such as dengue and influenza would be helped by a better understanding of how the B‐cell memory compartment responds to variant antigens. Towards this we have recently shown, after secondary immunization of mice with a widely variant dengue virus e...

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Detalles Bibliográficos
Autores principales: Tennant, Richard K., Holzer, Barbara, Love, John, Tchilian, Elma, White, Harry N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459774/
https://www.ncbi.nlm.nih.gov/pubmed/30768794
http://dx.doi.org/10.1111/imm.13052