Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane. Here we show that GSDME-N also permeabilizes the mitochondrial membrane, releasing cytochrome c and activating the apoptosome. Cytochrome c release and cas...

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Detalles Bibliográficos
Autores principales: Rogers, Corey, Erkes, Dan A., Nardone, Alexandria, Aplin, Andrew E., Fernandes-Alnemri, Teresa, Alnemri, Emad S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459836/
https://www.ncbi.nlm.nih.gov/pubmed/30976076
http://dx.doi.org/10.1038/s41467-019-09397-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459836/
https://www.ncbi.nlm.nih.gov/pubmed/30976076
http://dx.doi.org/10.1038/s41467-019-09397-2

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