Diverse small molecules prevent macrophage lysis during pyroptosis

Pyroptosis is a programmed process of proinflammatory cell death mediated by caspase-1-related proteases that cleave the pore-forming protein, gasdermin D, causing cell lysis and release of inflammatory intracellular contents. The amino acid glycine prevents pyroptotic lysis via unknown mechanisms,...

Descripción completa

Detalles Bibliográficos
Autores principales: Loomis, Wendy P., den Hartigh, Andreas B., Cookson, Brad T., Fink, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459844/
https://www.ncbi.nlm.nih.gov/pubmed/30975978
http://dx.doi.org/10.1038/s41419-019-1559-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459844/
https://www.ncbi.nlm.nih.gov/pubmed/30975978
http://dx.doi.org/10.1038/s41419-019-1559-4

Ejemplares similares