Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs

Carboxylic acids are common moieties in medicines. They can be converted to phthalidyl esters as prodrugs. Unfortunately, phthalidyl esters are now mostly prepared in racemic forms. This is not desirable because the two enantiomers of phthalidyl esters likely have different pharmacological effects....

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Detalles Bibliográficos
Autores principales: Liu, Yingguo, Chen, Qiao, Mou, Chengli, Pan, Lutai, Duan, Xiaoyong, Chen, Xingkuan, Chen, Hongzhong, Zhao, Yanli, Lu, Yunpeng, Jin, Zhichao, Chi, Yonggui Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459872/
https://www.ncbi.nlm.nih.gov/pubmed/30975988
http://dx.doi.org/10.1038/s41467-019-09445-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459872/
https://www.ncbi.nlm.nih.gov/pubmed/30975988
http://dx.doi.org/10.1038/s41467-019-09445-x

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