Conformational dynamics of the human serotonin transporter during substrate and drug binding

The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the presynaptic neuron. Its key role in synaptic transmission makes it a major drug target, e.g. for the treatmen...

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Detalles Bibliográficos
Autores principales: Möller, Ingvar R., Slivacka, Marika, Nielsen, Anne Kathrine, Rasmussen, Søren G. F., Gether, Ulrik, Loland, Claus J., Rand, Kasper D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459873/
https://www.ncbi.nlm.nih.gov/pubmed/30976000
http://dx.doi.org/10.1038/s41467-019-09675-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459873/
https://www.ncbi.nlm.nih.gov/pubmed/30976000
http://dx.doi.org/10.1038/s41467-019-09675-z

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