Cargando…

Conformational dynamics of the human serotonin transporter during substrate and drug binding

The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the presynaptic neuron. Its key role in synaptic transmission makes it a major drug target, e.g. for the treatmen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Möller, Ingvar R., Slivacka, Marika, Nielsen, Anne Kathrine, Rasmussen, Søren G. F., Gether, Ulrik, Loland, Claus J., Rand, Kasper D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459873/ https://www.ncbi.nlm.nih.gov/pubmed/30976000 http://dx.doi.org/10.1038/s41467-019-09675-z

Ejemplares similares

Substrate-induced conformational dynamics of the dopamine transporter
por: Nielsen, Anne Kathrine, et al.
Publicado: (2019)

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT
por: Merkle, Patrick S., et al.
Publicado: (2018)

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter
por: Plenge, Per, et al.
Publicado: (2020)

Mechanism of the Association between Na(+) Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters
por: Stolzenberg, Sebastian, et al.
Publicado: (2015)

The dopamine transporter antiports potassium to increase the uptake of dopamine
por: Schmidt, Solveig G., et al.
Publicado: (2022)

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
por: Erlendsson, Simon, et al.
Publicado: (2017)

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
por: Gotfryd, Kamil, et al.
Publicado: (2020)

Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations
por: Gabrielsen, Mari, et al.
Publicado: (2011)

Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates
por: Bhat, Shreyas, et al.
Publicado: (2017)

Determining Ligand and Ion-Induced Conformational Changes in Serotonin Transporter with Its Fluorescent Substrates
por: Li, Mu, et al.
Publicado: (2022)

Calmodulin kinase II regulates amphetamine-induced reverse transport in dopamine and serotonin transporters
por: Steinkellner, Thomas, et al.
Publicado: (2012)

Do the binding sites of substrates and tricyclic antidepressants overlap on the serotonin transporter?
por: Sarker, Subhodeep, et al.
Publicado: (2008)

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter
por: Plenge, Per, et al.
Publicado: (2021)

Conformational and dynamic plasticity in substrate-binding proteins underlies selective transport in ABC importers
por: de Boer, Marijn, et al.
Publicado: (2019)

Thermostabilisation of the Serotonin Transporter in a Cocaine-Bound Conformation
por: Abdul-Hussein, Saba, et al.
Publicado: (2013)

Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation
por: Green, Evan M., et al.
Publicado: (2015)

Substrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB
por: Wang, Beibei, et al.
Publicado: (2015)

Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain
por: Gradisch, Ralph, et al.
Publicado: (2022)

Evidence for a Role of Transporter-Mediated Currents in the Depletion of Brain Serotonin Induced by Serotonin Transporter Substrates
por: Baumann, Michael H, et al.
Publicado: (2014)

It takes two—or more—to tango: Revisiting the role of dopamine transporter oligomerization
por: Gether, Ulrik, et al.
Publicado: (2021)

Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity
por: Lycas, Matthew D., et al.
Publicado: (2022)

Exploring the Impact of BDNF Val66Met Genotype on Serotonin Transporter and Serotonin-1A Receptor Binding
por: Kraus, Christoph, et al.
Publicado: (2014)

Ligand Induced Conformational Changes of the Human Serotonin Transporter Revealed by Molecular Dynamics Simulations
por: Koldsø, Heidi, et al.
Publicado: (2013)

Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter
por: Billesbølle, Christian B., et al.
Publicado: (2016)

High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People
por: Kranz, Georg S., et al.
Publicado: (2015)

Identification of multiple substrate binding sites in SLC4 transporters in the outward-facing conformation: Insights into the transport mechanism
por: Zhekova, Hristina R., et al.
Publicado: (2021)

Serotonin Transporter Binding in Major Depressive Disorder: Impact of Serotonin System Anatomy
por: Bartlett, Elizabeth A, et al.
Publicado: (2022)

Assessment of Ketamine Binding of the Serotonin Transporter in Humans with Positron Emission Tomography
por: Spies, Marie, et al.
Publicado: (2017)

Is serotonin transporter brain binding associated with the cortisol awakening response? An independent non-replication
por: Conradi, Juliane, et al.
Publicado: (2023)

Substrate binding-induced conformational transitions in the omega-3 fatty acid transporter MFSD2A
por: Bergman, Shana, et al.
Publicado: (2023)

Conditioned Pain Modulation Is Associated with Common Polymorphisms in the Serotonin Transporter Gene
por: Lindstedt, Fredrik, et al.
Publicado: (2011)

Mechanism of substrate binding and transport in BASS transporters
por: Becker, Patrick, et al.
Publicado: (2023)

Mechanism of substrate binding and transport in BASS transporters
por: Becker, Patrick, et al.
Publicado: (2023)

Perception of Thermal Pain and the Thermal Grill Illusion Is Associated with Polymorphisms in the Serotonin Transporter Gene
por: Lindstedt, Fredrik, et al.
Publicado: (2011)

Unbiased Simulations Reveal the Inward-Facing Conformation of the Human Serotonin Transporter and Na(+) Ion Release
por: Koldsø, Heidi, et al.
Publicado: (2011)

Effects of substrate conformational strain on binding kinetics of catalytic antibodies
por: Oda, Masayuki, et al.
Publicado: (2016)

Role of Repeated Conformational Transitions in Substrate Binding of Adenylate Kinase
por: Lu, Jiajun, et al.
Publicado: (2022)

Serotonin and serotonin transporter levels in autistic children
por: Abdulamir, Haidar A., et al.
Publicado: (2018)

The Environment Shapes the Inner Vestibule of LeuT
por: Sohail, Azmat, et al.
Publicado: (2016)

Amphetamine-induced reverse transport of dopamine does not require cytosolic Ca(2+)
por: Støier, Jonatan Fullerton, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_66c2rkvhhke7ea68sti6dhfvcj