Akt inhibitor SC66 promotes cell sensitivity to cisplatin in chemoresistant ovarian cancer cells through inhibition of COL11A1 expression

We studied Akt inhibition using SC66 in a NOD-SCID xenograft mouse model and a panel of eight ovarian cancer cell lines. Elevated phospho-Akt levels in cancerous tissue were associated with short progression-free survival and overall survival. Cell sensitivity to SC66 was inversely correlated with p...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Yi-Hui, Huang, Yu-Fang, Chen, Chien-Chin, Chou, Cheng-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459878/
https://www.ncbi.nlm.nih.gov/pubmed/30975980
http://dx.doi.org/10.1038/s41419-019-1555-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459878/
https://www.ncbi.nlm.nih.gov/pubmed/30975980
http://dx.doi.org/10.1038/s41419-019-1555-8

Ejemplares similares