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Akt inhibitor SC66 promotes cell sensitivity to cisplatin in chemoresistant ovarian cancer cells through inhibition of COL11A1 expression

We studied Akt inhibition using SC66 in a NOD-SCID xenograft mouse model and a panel of eight ovarian cancer cell lines. Elevated phospho-Akt levels in cancerous tissue were associated with short progression-free survival and overall survival. Cell sensitivity to SC66 was inversely correlated with p...

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Detalles Bibliográficos
Autores principales:	Wu, Yi-Hui, Huang, Yu-Fang, Chen, Chien-Chin, Chou, Cheng-Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459878/ https://www.ncbi.nlm.nih.gov/pubmed/30975980 http://dx.doi.org/10.1038/s41419-019-1555-8

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